Medical Supervision: Dr. K.D. Nayar (MBBS, MS, FICOG | DMC Reg No: 14778)
Psychological Support: Dr. Poonam Nayar (Clinical Psychologist | RCI Reg No: [INSERT_RCI_NO])
Experiencing two or more unsuccessful IVF cycles requires systematic clinical assessment to identify underlying factors. Recurrent Implantation Failure (RIF) is evaluated at Akanksha IVF Centre using evidence-based diagnostic protocols to investigate embryonic, uterine, and systemic causes.
Schedule a Clinical Evaluation – Call 098103 98765
Defining Recurrent IVF Failure
Recurrent IVF Failure (or Recurrent Implantation Failure – RIF) is clinically defined as the absence of a confirmed clinical pregnancy following the transfer of high-quality embryos across multiple IVF cycles. This is distinct from recurrent pregnancy loss, where implantation occurs prior to pregnancy termination.
Clinical Etiologies in Repeated Failure
1. Embryonic Factors
- Advanced maternal age affecting oocyte quality
- Semen parameters and high sperm DNA fragmentation index (DFI)
- Embryonic chromosomal aneuploidy
2. Uterine & Anatomical Factors
- Suboptimal endometrial thickness or receptivity
- Intrauterine pathologies (polyps, submucosal fibroids, intrauterine synechiae)
- Hydrosalpinx causing fluid reflux into the uterine cavity
- Adenomyosis
3. Systemic & Immunological Factors
- Antiphospholipid Syndrome (APS) and inherited thrombophilias
- Immunological and autoimmune variations
- Uncontrolled metabolic or endocrine disorders (e.g., thyroid dysfunction)
Diagnostic Protocol for Recurrent Implantation Failure
Clinical evaluation involves structured diagnostic testing prior to initiating subsequent treatment cycles:
- Advanced semen analysis and Sperm DNA Fragmentation Index (DFI) assessment
- Ovarian reserve testing (AMH and Antral Follicle Count)
- 3D transvaginal ultrasound and diagnostic hysteroscopy
- Endometrial Receptivity Analysis (ERA) to assess the window of implantation
- Thrombophilia and immunological blood screening
- Endocrine and metabolic screening
Clinical Interventions & Advanced ART Options
- Preimplantation Genetic Testing (PGT-A): Chromosomal screening of blastocysts prior to transfer.
- Microfluidic Sperm Sorting (MFSS): Sperm selection protocols for high DFI cases.
- Endometrial Receptivity Analysis (ERA): Tailoring transfer timing to the individual window of implantation.
- Diagnostic & Operative Hysteroscopy: Surgical correction of intrauterine abnormalities.
- Time-Lapse Embryo Monitoring: Uninterrupted incubation and morphokinetic embryo evaluation.
- Medical Management of Thrombophilia: Targeted anticoagulant or antiplatelet therapy when indicated.
Frequently Asked Questions
When should detailed investigations for RIF begin?
Comprehensive clinical investigations are recommended when two or more IVF cycles fail to result in pregnancy despite transferring suitable quality embryos.
What is the purpose of the ERA test?
The Endometrial Receptivity Analysis identifies whether the endometrial window of implantation is standard or displaced, enabling personalized timing for embryo transfer.
Are subsequent cycles modified after evaluation?
Yes. Based on diagnostic findings (e.g., uterine, genetic, or immunological parameters), stimulation protocols, embryology techniques, and transfer timing are adapted individually.
Clinical Consultations & Appointments
For inquiries regarding diagnostic evaluations for Recurrent Implantation Failure, contact our outpatient department.
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