Recurrent IVF Failure Treatment in Delhi – Akanksha IVF Centre
If you have had two or more IVF cycles that failed to result in pregnancy, you are not alone — and you have not run out of options. Recurrent IVF failure is a deeply distressing experience, but in the majority of cases, the underlying reason can be identified and addressed with the right expertise.
At Akanksha IVF Centre, Janakpuri, New Delhi, Dr. K.D. Nayar — with over 40 years of IVF experience and special expertise in Poor Ovarian Response and Recurrent Implantation Failure — has helped hundreds of couples succeed after multiple failed cycles elsewhere. He is the author of India’s first evidence-based guidelines on Poor Ovarian Response, published in a global journal.
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What is Recurrent IVF Failure?
Recurrent IVF failure (also called Recurrent Implantation Failure or RIF) is generally defined as failure to achieve a clinical pregnancy after transfer of at least 3–4 good-quality embryos in two or more IVF cycles. It is different from recurrent miscarriage, where implantation occurs but the pregnancy is lost.
Why Does IVF Fail Repeatedly? Common Causes
Embryo-Related Factors
- Poor egg quality — especially with advancing age
- Poor sperm quality or high DNA fragmentation
- Chromosomal abnormalities in embryos (aneuploidy)
- Suboptimal embryo culture conditions
Uterine Factors
- Thin or inadequate endometrium (uterine lining)
- Uterine fibroids, polyps, or adhesions inside the cavity
- Hydrosalpinx (fluid from blocked tube leaking into uterus)
- Adenomyosis — endometrial tissue inside the uterine muscle
- Endometrial receptivity issues (ERA test)
Immune and Blood Clotting Factors
- Antiphospholipid syndrome (blood clotting disorder)
- Natural Killer (NK) cell abnormalities
- Thrombophilia — increased tendency for blood clots in uterine vessels
Lifestyle and Other Factors
- Smoking, alcohol, high BMI
- Uncontrolled thyroid or diabetes
- Poor stimulation protocol in previous cycles
- Inadequate luteal phase support
Our Recurrent IVF Failure Investigation Protocol
Dr. K.D. Nayar conducts a thorough review of all your previous IVF records and prescribes targeted investigations:
- Detailed semen analysis + Sperm DNA Fragmentation Test
- Advanced ovarian reserve testing (AMH, AFC)
- 3D ultrasound and hysteroscopy to evaluate uterine cavity
- ERA (Endometrial Receptivity Analysis) test for optimal transfer timing
- Thrombophilia and immunological blood panel
- Thyroid, prolactin, and metabolic workup
- Review of embryology lab records from previous cycles
Advanced Treatments We Offer for Recurrent IVF Failure
- Preimplantation Genetic Testing (PGT-A) — Testing embryos for chromosomal abnormalities before transfer, selecting only normal embryos
- Microfluidic Sperm Sorting (MFSS) — Better sperm selection to improve embryo quality
- ERA Test + Personalised Embryo Transfer (pET) — Transfer at the exact window of implantation unique to your uterus
- Hysteroscopy — Identifying and removing polyps, fibroids, or adhesions inside the uterus before the next cycle
- Time-Lapse Embryo Imaging — Better embryo selection using continuous, undisturbed monitoring
- Immunotherapy — For identified immune-related implantation failure
- Anticoagulation therapy — For thrombophilia and antiphospholipid syndrome
- Donor eggs — When poor egg quality is the primary issue, especially in older women
Frequently Asked Questions – Recurrent IVF Failure
How many IVF failures before trying something different?
If you have had 2 or more failed IVF cycles, we recommend a thorough investigation before proceeding to the next cycle. Repeating the same protocol without investigating the cause is rarely effective.
Can I still get pregnant after multiple IVF failures?
Yes. With proper investigation and modified protocols, many couples who have had 3–5 failed cycles go on to have successful pregnancies. Dr. K.D. Nayar’s specific expertise in recurrent implantation failure means he can identify issues that were missed in previous treatments.
What is the ERA test and do I need it?
The ERA (Endometrial Receptivity Analysis) test assesses whether your uterine lining is receptive to embryo implantation at the standard time of transfer. Some women have a “displaced window of implantation” — the ERA test identifies this, allowing transfer to be timed perfectly for your uterus. It is recommended for women who have had multiple failed transfers with good embryos.
Is it worth trying IVF again after 3 failures?
Yes, if a proper investigation has been done and the cause identified. Success rates after a thorough workup and protocol change are significantly better than simply repeating the same treatment.
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